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Search for "natural product biosynthesis" in Full Text gives 8 result(s) in Beilstein Journal of Organic Chemistry.
Chemoenzymatic synthesis of macrocyclic peptides and polyketides via thioesterase-catalyzed macrocyclization
Beilstein J. Org. Chem. 2024, 20, 721–733, doi:10.3762/bjoc.20.66
- -product biosynthesis and combinatorial solid-phase chemistry, this strategy has expanded the sequence space of macrocyclic peptides significantly (Scheme 2c). The daptomycins The calcium-dependent antibiotic (CDA, 11), daptomycin (12), and A54145 are acidic lipopeptides isolated from Streptomycetes, which
- biomimetic linker to imitate peptide-S-PCP [46], which not only employed in the efficient cyclization of tyrocidine A (1) but also worked on hundreds of other linear substrates, some of which exhibited broad-spectrum activity against both Gram-positive and Gram-negative organisms. By combining natural
Navigating and expanding the roadmap of natural product genome mining tools
Beilstein J. Org. Chem. 2022, 18, 1656–1671, doi:10.3762/bjoc.18.178
- combination of all genome mining approaches will pave the way towards a more comprehensive understanding of the full biosynthetic repertoire encoded in microbial genome sequences. Keywords: genome mining; natural product biosynthesis; non-canonical pathways; PKS; NRPS; RiPP; Introduction In 2002, the genome
Enzymes in biosynthesis
Beilstein J. Org. Chem. 2022, 18, 1131–1132, doi:10.3762/bjoc.18.116
- -Institut for their professional support. I wish the readers of this issue some stimulating new insights into enzyme research in natural product biosynthesis. Jeroen S. Dickschat Bonn, August 2022
α-Ketol and α-iminol rearrangements in synthetic organic and biosynthetic reactions
Beilstein J. Org. Chem. 2021, 17, 2570–2584, doi:10.3762/bjoc.17.172
- continued development in these areas can be expected in the coming years. It is becoming apparent that nature also utilizes these rearrangements in natural product biosynthesis, and one might expect to see an increase in the discovery of enzymes governing these reactions. Generalized α-ketol or α-iminol
Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B
Beilstein J. Org. Chem. 2021, 17, 2390–2398, doi:10.3762/bjoc.17.156
- hypotheses not previously reported in natural product biosynthesis. Experimental General experimental procedures IR spectra were acquired on a Perkin Elmer Spectrum Two FT-IR spectrometer equipped with an ATR diamond cell. Optical rotations were measured on an ADP 410 digital Polarimeter (Bellingham
Sulfation and amidinohydrolysis in the biosynthesis of giant linear polyenes
Beilstein J. Org. Chem. 2017, 13, 2408–2415, doi:10.3762/bjoc.13.238
- before or after the specific sulfonation step. The sequence of the sulfotransferase is a useful probe to uncover related gene clusters in public sequence databases. Sulfonation remains a rare and relatively poorly understood modification in natural product biosynthesis [27][28][29][30]. As our
Antibiotics from predatory bacteria
Beilstein J. Org. Chem. 2016, 12, 594–607, doi:10.3762/bjoc.12.58
- possess impressive capacities for natural product biosynthesis. Here, we will present the results from recent chemical investigations of this bacterial group, compare the biosynthetic potential with that of non-predatory bacteria and discuss the link between predation and secondary metabolism. Keywords
- , it becomes obvious that the Cystobacterineae strains consistently possess more biosynthesis gene clusters per Mbp of DNA than the analyzed Sorangiineae and that they also devote a larger percentage of their total nucleotides to natural product biosynthesis. Noteworthy in this context, the genera
Heronapyrrole D: A case of co-inspiration of natural product biosynthesis, total synthesis and biodiscovery
Beilstein J. Org. Chem. 2014, 10, 1228–1232, doi:10.3762/bjoc.10.121
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